Breakdown: mechanical dysfunction and anthropomorphism

Breakdown: Mechanical Dysfunction and Anthropomorphism is a practice-led research project examining the role of mechanical breakdown in the anthropomorphic process. Current theoretical approaches to mechanical breakdown identify it as a homogenous, revelatory event “a sort of breach opened up by objects.” (Baudrillard, 2004: 62). Breakdown challenges this stereotyping and seeks to examine the range of gesture and affect that differing forms of mechanical breakdown exhibit. In doing so it also develops Sherry Turkle’s notion of anthropomorphism as a connective rather than ascriptive process (2005: 351) in the light of Karen Barad’s “performative account of material bodies” (2007: 139). Leading this research is Breakdown, the making, remaking, exhibition and reexhibition of 36 breaking-machines. These breaking-machines; simple mechanical devices made from reconfigured found materials; approach breakdown and fail during their exhibition. They are then repaired or reconfigured by the artist ‘live’ while still on show. Throughout the research this role of the artist as repairman became a key method. The continual recombination of human and machine responding to the call of breakdown allowed for a more detailed understanding of the gestures of mechanical breakdown. This performative relationship considers the posthuman decentring of the Vitruvian man in the writing of Rosi Braidotti (2013: 2) and Karen Barad’s agential realism (Barad, 2007: 44) both of which insist that the human, rather than bounded and individual, be considered as part of a dispersed network of interacting parts. The thesis begins by investigating the performative relationship of Breakdown in detail. It describes a machine-human body that is materialised fleetingly by mechanical dysfunction. Through an intimate relationship with one machine, it then goes on to identify a typology of breakdown: seize, play, burnout and cutting loose, concluding that each emits differing expanding and contracting forces around which bodies disperse and coalesce. Finally, employing the flicker of a thaumatrope and the making of the science fiction film robot, the thesis posits that anthropomorphism is an integral element in the dissipation and reformation of human-machine bodies

Associations of hemoglobin A1c with cognition reduced for long diabetes duration

IntroductionAssociations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration.MethodsThe interaction of mean hemoglobin A1c (averageâ =â 9.8%), evaluated over duration (averageâ =â 116.8â months), was examined for overall cognition and three cognitive domains in a sample of 150 â youngâ oldâ veterans (mean ageâ =â 70) with type 2 diabetes.ResultsThe predicted interactions were significant for overall cognition and attention, but not executive functions/language and memory.DiscussionFindings extend the Protected Survivor Model to a â youngâ oldâ sample, from the very old. This model suggests focusing on individuals with good cognition despite prolonged high risk when seeking protective factors.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152553/1/trc2jtrci201911009.pd

A common framework for approaches to extreme event attribution

The extent to which a given extreme weather or climate event is attributable to anthropogenic climate change is a question of considerable public interest. From a scientific perspective, the question can be framed in various ways, and the answer depends very much on the framing. One such framing is a risk-based approach, which answers the question probabilistically, in terms of a change in likelihood of a class of event similar to the one in question, and natural variability is treated as noise. A rather different framing is a storyline approach, which examines the role of the various factors contributing to the event as it unfolded, including the anomalous aspects of natural variability, and answers the question deterministically. It is argued that these two apparently irreconcilable approaches can be viewed within a common framework, where the most useful level of conditioning will depend on the question being asked and the uncertainties involved

Constitutivism

A brief explanation and overview of constitutivism

Human BRCA1-BARD1 ubiquitin ligase activity counters chromatin barriers to DNA resection

The opposing activities of 53BP1 and BRCA1 influence pathway choice of DNA double-strand break repair. How BRCA1 counters the inhibitory effect of 53BP1 on DNA resection and homologous recombination is unknown. Here we identify the site of BRCA1-BARD1 required for priming ubiquitin transfer from E2~ubiquitin. We demonstrate that BRCA1-BARD1’s ubiquitin ligase activity is required for repositioning 53BP1 on damaged chromatin. We confirm H2A ubiquitylation by BRCA1-BARD1 and show that an H2A-ubiquitin fusion protein promotes DNA resection and repair in BARD1 deficient cells. We show BRCA1-BARD1 function in homologous recombination requires the chromatin remodeler SMARCAD1. SMARCAD1 binding to H2A-ubiquitin, optimal localization to sites of damage and activity in DNA repair requires its ubiquitin-binding CUE domains. SMARCAD1 is required for 53BP1 repositioning and the need for SMARCAD1 in Olaparib or camptothecin resistance is alleviated by 53BP1 loss. Thus BRCA1- BARD1 ligase activity and subsequent SMARCAD1-dependent chromatin remodeling are critical regulators of DNA repair

Impact of changing computer technology on hydrologic and water resource modeling

The increasing availability of substantial computer power at relatively low costs and the increasing ease of using computer graphics, of communicating with other computers and data bases, and of programming using high-level problem-oriented computer languages, is providing new opportunities and challenges for those developing and using hydrologic and water resources models. This paper reviews some of the progress made towards the development and application of computer support systems designed to aid those involved in analyzing hydrologic data and in operating, managing, or planning water resource facilities. Such systems of hardware and software are being designed to allow direct and easy access to a broad and heterogeneous group of users. These systems often combine data-base management; simulation and optimization techniques; symbolic colored displays; heuristic, qualitative approaches; and possibly artificial intelligence methods in an interactive, user-controlled, easily accessible interface. Individuals involved in the use of such systems are not only those with technical training, but also those representing different interest groups and having non-technical backgrounds. The essential difference between what is happening now and the more traditional off-line, non-interactive approaches is that instead of generating solutions to specific problems, model developers are now beginning to deliver, in a much more useful and user-friendly form, computer-based turnkey systems for exploring, analyzing and synthesizing plans or policies. Such tools permit the user to evaluate alternative solutions based on his or her own objectives and subjective judgments in an interactive learning and decision-making process

Philosophy of action

The philosophical study of human action begins with Plato and Aristotle. Their influence in late antiquity and the Middle Ages yielded sophisticated theories of action and motivation, notably in the works of Augustine and Aquinas.1 But the ideas that were dominant in 1945 have their roots in the early modern period, when advances in physics and mathematics reshaped philosophy